PTEN and breast carcinoma: While the isoform of PAX8-AS1 is named PAX8-AS1-N, it can bind to miR-17-5p and upregulate miR-17-5p targets, such as PTEN, CDKN1A, and ZBTB4. The reduced expression of PAX8-AS1-N indicated poor survival of breast cancer patients [30].