In this sense, although many functional aspects of CNAs at chr X and chr Y have not yet been extensively studied in cancer, a preliminary study suggested that high expression of SPIN4 and ASB12 was correlated with amplification at Xq11 in GBM (11), thus affecting several important biological processes, such as mitosis, Wnt signaling pathway, H3K4me3, and post-translational protein modifications. Here, SPIN4 is linked to glioblastoma.