Perhapsthe addition of an anti-VEGF agent at the time of the laser-induced inflammatoryinsult prevents the macular edemainducing effects of releasedcytokines(19,20), such that patients treated with PRP+anti-VEGF becomesimilar to patients treated with anti-VEGF alone with respect to the number ofintravitreal injections necessary to control macular edema(21). Here, VEGFA is linked to macular retinal edema.