PTCH1 and Mobius syndrome: A role for REST in the progression of SHH‐driven MBs was first described by our previous work, where we showed that in Ptch+/− mice with constitutive activation of SHH signaling, REST elevation (Ptch+/−/RESTTG) promoted tumors with 100% penetrance, accelerated kinetics of 10–90 days, and leptomeningeal dissemination [10].