SHH and neoplasm: In the background of constitutive activation of SHH signaling (Ptch+/−), RESTTG mice developed poorly differentiated tumors with 100% penetrance, accelerated kinetics of 10–90 days, and leptomeningeal dissemination when compared to Ptch+/− mice, which highlighted a cell‐intrinsic role for the protein in tumor progression [10].