Like CD31, VEGFR1 gene expression was significantly higher in SHH‐α, SHH–β, SHH–γ MBs compared with SHH‐δ tumors, and VEGFR1 and REST expression showed a strong overall positive correlation (r = 0.29, P < 0.0001) in SHH subgroup of MB samples and in SHH‐γ (r = 0.30, P = 0.04) and SHH‐δ subtypes (r = 0.23, P = 0.047) (Figs 5G,H and S10E). Here, REST is linked to Mobius syndrome.