ACE2 and calcification: In a recent clinical study, elevated (higher than the median) ACE2 plasma activity was found as an independent predictor of all-cause mortality (HR: 2.28; 95% CI: 1.03 to 5.06; P = 0.042) and in correlation with increased valvular calcification (p = 0.023) and left ventricular (LV) mass index (r = 0.34; P < 0.001) [18].