EZH2 and hepatocellular carcinoma: By performing chromatin immunoprecipitation promoter array and gene expression analyses in hepatocellular carcinoma, Cheng et al. (2011) found that enhancer of zeste homolog 2 (EZH2) occupancy of the promoter decreased the expression of several Wnt antagonists including Axin2, NKD1, PPP2R2B, DKK1, and SFRP5.