The rs1136451 of the SFTPA1 is associated with increased risk, whereas, the rs1136450 and the rs1130866 of the SFTPA1 and SFTPB, respectively, are associated with decreased risk of HP compared to non-exposed controls using logistic regression analysis and a single-SNP model. The gene discussed is SFTPA1; the disease is hypersensitivity pneumonitis.