PPARGC1A and Parkinson disease: A study using a 6-OHDA lesioned rat model of PD showed that the polyphenolic phytochemical ferulic acid can modulate PGC1α with beneficial effects on mitochondrial dynamics, supporting the concept of targeting PGC1α, a master regulator of mitochondrial biogenesis, as a therapeutic strategy (Anis et al., 2020; Bennett and Keeney, 2020).