These results educed two new possible metabolic targets to hamper tumor angiogenesis; aldehyde dehydrogenase 18 family member A1 (ALDH18A1), an enzyme essential for de novo biosynthesis of proline; and squalene epoxidase (SQLE), the rate-limiting enzyme in cholesterol biosynthesis. The gene discussed is ALDH18A1; the disease is neoplasm.