PFKFB3 and neoplasm: TECs exhibit upregulated glycolysis due to elevated expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which regulates proliferation and migration during tumor angiogenesis (van der Veldt et al., 2012; de Bock et al., 2013).