LYZ and infection: Disturbances of AMP packaging into granules and alterations in the granule exocytosis pathway are reflected by disorganized and reduced numbers of cytoplasmic granules as well as a diffuse cytoplasmic lysozyme expression, and represent a common phenomenon under inflammatory conditions like IBD and infections, but also upon injury, defects in autophagy, or MT-UPR induction (Figure 2B).