Consistently, changes in metabolism as well as mitochondrial genes and proteins have been described in IECs from IBD patients (Mottawea et al., 2016; Rath et al., 2018; Haberman et al., 2019) along with aberrant patterns of LGR5 expression and reduced PC function (Wehkamp et al., 2005; VanDussen et al., 2014; Khaloian et al., 2020). The gene discussed is LGR5; the disease is inflammatory bowel disease.