MKI67 and infection: For semi-quantitative analysis for CK19 and Ki67 expression, compared with non-infection and TLR4wild-infected mice, TLR4def infected mice showed higher expression of CK19 and Ki67 (as indicated by arrow), suggesting that TLR4def infected mice had more bile duct hyperplasia than TLR4wild infected mice (Figure 3A for CK19, and Figure 3B for Ki67, P<0.01).