An increased expression of CD47 has been demonstrated in multiple solid and hematological malignancies compared with normal cells, including but not limited to breast (19), small-cell lung (20), colon (21), ovarian (22), acute myeloid leukemia (AML) (23), and acute lymphocytic leukemia (ALL) (24) malignancies. This evidence concerns the gene CD47 and acute myeloid leukemia.