As shown in Figure 2, in breast cancer tissues, the expression of nuclear ING3 in pathological grade III group (13/52) was lower than that in pathological grade I–II group (85/159) (χ2 = 12.759, P<0.001) (Figures 2A, B), which suggested that the nuclear ING3 expression was negatively correlated with the histological grade (P<0.001) (Figure 2C). The gene discussed is ING3; the disease is breast carcinoma.