In response to various stimuli, including proinflammatory cytokines tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β), lipopolysaccharides (LPS), and the viral or bacterial infections, the IκB proteins are rapidly phosphorylated by upstream IκB kinases (IKKs) (8, 9). The gene discussed is TNF; the disease is bacterial infectious disease.