IL6 and juvenile idiopathic arthritis: Increased understanding of the role of cytokines has resulted in studies confirming the value of anti-cytokine therapy [anti–tumor necrosis factor (anti-TNF) and interleukin 6 (IL-6) therapy] in severe and recurrent cases of AAU, particularly in subjects with an associated spondyloarthopathy (SpA) and in juvenile idiopathic arthritis (JIA)–associated AAU.