IPA analysis indicated that this delay in apoptosis was via the up-regulation of the NFκB transcription factor complex (p=2.9x10-8) in response to activation of TNF receptors 1 and 2 (TNFR1 signaling p=10-2; TNFR2 signaling p=10-3) in RA SF neutrophils (Figure 4C). Here, TNFRSF1B is linked to rheumatoid arthritis.