Chemokines up-regulated in RA SF (Figure 2B) included those associated with attraction of both innate and adaptive immune cells, including other neutrophils (CXCL8, CXCL1, CXCL2), T cells, monocytes and macrophages, natural killer cells, and dendritic cells (CXCL16, CXCL10, CCL2, CCL3, CCL4) (31–33). This evidence concerns the gene CCL2 and rheumatoid arthritis.