CD8A and type 1 diabetes mellitus: On the other hand, other studies demonstrated no significant differences between T1D and control individuals in the frequencies of circulating CD8 T cells reactive to multiple A*02:01-restricted beta-cell epitopes (PPI14-25, PPI6-14, InsB10-18, GAD114-123, IA-2797-805, IA-2805-813, IGRP265-273, ZnT8186-194) (3, 4, 6, 10).