Both STIM2 (Sun et al., 2014; Zhang et al., 2015) and STIM1 (Zeiger et al., 2013) have been implicated in the regulation of amyloid-beta peptide, which has been shown to accumulate in AD (Zeiger et al., 2013), and have been shown to regulate the formation of dendritic spines in a mouse model of AD (Sun et al., 2014; Zhang et al., 2015). Here, STIM1 is linked to Alzheimer disease.