MYC and breast cancer: The data showed that lncRNA KB-1980E6.3 knockdown had no impact on the promoter activity of c-Myc in normoxic or hypoxic breast cancer cells, however, the transcription potential of c-Myc, a known target of STAT3, was reduced in STAT3 silencing group (Fig. 5a, b), indicating that lncRNA KB-1980E6.3 may regulate c-Myc at the posttranscriptional level.