MYC and neoplasm: As shown in Fig. 7e, significantly stable c-Myc mRNA was detected in hypoxic BT549 cells with ectopic WT c-Myc CRD rather than mutant c-Myc CRD; the loss of lncRNA KB-1980E6.3 or IGF2BP1 dramatically decreased the stability of c-Myc mRNA in hypoxic tumor cells.