Knockdown of lncRNA KB-1980E6.3 or IGF2BP1 in Hs578T CSCs significantly decreased tumor initiation and tumor growth in comparison with their control groups; however, ectopic c-Myc could effectively rescue tumor initiation and tumor growth caused by lncRNA KB-1980E6.3 silencing or IGF2BP1 knockdown in bevacizumab-administrated mice (Figs. 8a, b, and S9a, b). Here, MYC is linked to neoplasm.