TNFRSF17 and neoplasm: A next-generation sequence (NGS)-based antibody discovery platform established in 2019 to identify anti-CD3 antibodies from humanised rats that bind to multiple CD3 epitopes with a diverse range of binding strengths was used to identify lead anti-CD3-binding domains, which were then formatted as bispecific antibodies.35 In particular, the anti-CD3 × anti-BCMA bispecific T-cell redirector that emerged from this antibody screen was shown to elicit robust tumour antigen-specific killing in a mouse xenograft model with almost undetectable cytokine release.