KDM6A and autoimmune disease: These data add to a number of studies implicating KDM6A in immune responses against viral infections and in autoimmune diseases.13 At a molecular level, KDM6A is known to have an opposing role to EZH2 (enhancer of Zeste homologue 2) in the PRC2 complex in methylation of Lys 27 on H3 histone.