These data add to a number of studies implicating KDM6A in immune responses against viral infections and in autoimmune diseases.13 At a molecular level, KDM6A is known to have an opposing role to EZH2 (enhancer of Zeste homologue 2) in the PRC2 complex in methylation of Lys 27 on H3 histone. This evidence concerns the gene KDM6A and viral infectious disease.