In our animal models of oral cancer, C-87 reduced tumor size, along with the reduction of several proinflammatory markers/chemokines such as NGF, IL-1β, IL-33, and MIP3α that have been implicated in cancer proliferation, epithelial mesenchymal transition, transmigration, and extracellular matrix breakdown8,44–48. The gene discussed is IL1B; the disease is neoplasm.