Furthermore, PcG members EZH2, a human homolog of Drosophila E(z) protein, EED (Esc in Drosophila), SUZ(12) (Drosophila Su(z)12) and BMI-1(homolog of Drosophila Psc) have been shown to have a role in different cancers in knock out studies carried out in cell lines as well as in mouse model51–54. Here, SUZ12 is linked to cancer.