SERPINA6 and heart disorder: We aimed: to identify additional specific loci influencing cortisol; to refine where in the SERPINA6/A1 locus there is an influence on cortisol; to establish whether SERPINA6/A1 variation influences tissue-specific expression of CBG and α1-antitrypsin; and to confirm whether high cortisol is causal in ischaemic heart disease and test if it is causal in other common diseases.