CXCR3 and neoplasm: When T cells derived from vaccinated mice were co-cultured with irradiated TC-1 tumor cells, the population of CXCR3+CD8+ T cells was higher than that when co-cultured with non-irradiated TC-1 cells, or when non-vaccinated T cells were co-cultured with irradiated TC-1 cells (Fig. 5c).