Further findings regarding the metabolic role of adipocyte size/source showed that although all the study population showed clinically significant insulin resistance, as assessed by HOMA-IR; larger adipocytes from SAT were associated with a worse gluco-metabolic profile, denoted by significantly higher plasma glucose, HbA1c and lower plasma insulin, as compared with larger adipocytes from VAT. The gene discussed is INS; the disease is Insulin resistance.