The recruitment of CD8+ T cells into tumor tissues might be due to the secreted chemokines and cytokines by Met@Man-MPs-reset macrophages, such as TNF-α, since TNF-α expression and secretion was significantly upregulated in Met@Man-MPs-treated M2-like macrophages, and Etan, an inhibitor of TNF-α, significantly decreased the recruitment of CD8+ T cells by Met@Man-MPs-treated M2-like macrophages by transwell migration assay. The gene discussed is CD8A; the disease is neoplasm.