Meanwhile, tumor immune microenvironment analysis showed that Met@Man-MPs significantly increased the percentages of M1-like TAMs (Fig. 9c), CD8+ T cells (Fig. 9e), activated CD8+ T cells (Fig. 9f), and activated CD4+ T cells (Fig. 9h), while decreased the percentages of M2-like TAMs (Fig. 9d), MDSCs (Fig. 9i) and Tregs (Fig. 9j). This evidence concerns the gene CD4 and neoplasm.