CD8A and neoplasm: To determine whether Met@Man-MPs-induced CD8+ T cell infiltration was due to the recruitment by the repolarization of M2-like TAM to M1 phenotype and the degradation of tumor ECM, H22 tumor-bearing mice were intravenously injected with Met@Man-MPs pretreated with or without Bati or/and intraperitoneal injection of Etan (Fig. 6a).