MRC1 and neoplasm: Due to the tumor-targeting capacity of macrophages-derived MPs and high CD206 expression in TAMs (Supplementary Fig. 8), PKH26 fluorescence in TAMs was significantly higher than that in Kupffer cells, splenic macrophages, splenic DCs, and pulmonary macrophages at 24 h after intravenous injection of PKH26-labeled Man-MPs (Fig. 2g), excluding the targeting accumulation of Man-MPs in other tissue-resident macrophages and phagocytes.