For example, a ZEB2–LSD1 interaction is essential for the survival of T-ALL cells with high ZEB2 levels, which are sensitive to LSD1 inhibitors.141 Moreover, some inhibitors were developed to interfere with LSD1–GFI1/CoREST complex functions, including blockade of its scaffolding and enzymatic functions or displacement of LSD1 from the GFI1 repressor complex.142,143 However, TF-HDT interplay is subject to regulation by protein modifications. The gene discussed is ZEB2; the disease is acute lymphoblastic leukemia.