SALL4 and acute myeloid leukemia: Knockdown of the NuRD complex not only prevents histone deacetylation and chromatin compaction but also impairs DNA and histone methylation, thus promoting cellular differentiation.72,73 In addition, the stem cell factor SALL4 contributes to AML leukemogenesis by recruiting the NuRD/HDAC complex to the PTEN and SALL1 promoters and suppressing their expression.