ZFPM1 and Splenomegaly: Knock-in mice bearing three adjacent point mutations (R3G, R4G, and K5A) within the NuRD-binding module of FOG-1 that abrogate NuRD binding displayed thrombocytopenia and anemia with splenomegaly and extramedullary hematopoiesis.61 Furthermore, mice harboring disrupted FOG1/NuRD interaction (Fogki/ki) produced Fogki/ki CMPs and Fogki/ki MEPs that gave rise to significantly fewer and more immature MKs and erythroid colonies while retaining multilineage capacity to differentiate into Mast cells (MCs) and other myeloid lineage cells in vitro.