The imitation switch (ISWI) is an evolutionarily conserved CRC that contains SNF2H/SMARCA5 or SNF2L/SMARCA1 as the ATPase subunit and a C-terminal SANT domain adjacent to a SLIDE domain (SANT-like ISWI), which together form a nucleosome recognition module. This evidence concerns the gene SMARCA5 and colorectal carcinoma.