In inv(16) acute myeloid leukemia (AML), the CBFβ–MYH11/RUNX1 complex interacts with TAFs and occupies genomic regions that have been implicated in hematopoietic stem cell self-renewal, such as TBP and RNAPII.6 The TAF/TF interaction region or promoter recognition domains of TAFs may provide a therapeutic target to disrupt abnormal transcription programs. The gene discussed is RUNX1; the disease is acute myeloid leukemia.