HSP90AA1 and cancer: Accumulating evidence has shown that Hsp90 chaperone machinery is a key regulator of cellular process by interacting with the client proteins, assisting their correct folding, and increasing their stability as well as their activity.19 Among the client proteins of Hsp90, there are a lot of proteins that are involved in cancer progression, which makes Hsp90 a promising target for anti-cancer therapy.