SHANK2 and pulmonary emphysema: In our fetal lung aDMPs, we found previously discussed differentially methylated age-associations identified in fetal brain tissue [13] including the Wnt antagonist SFRP1 known to be differentially methylated in adults with asthma [41] and previously associated with emphysema [42], nuclear receptor gene NR4A2 crucial for neurogenesis and SHANK2 implicated in neurodevelopmental disorders such as autism and severe asthma [13, 43].