Stimulation of cultured human colonic cancer epithelial (CaCo-2) cells with 5-ASA induced expression of PPARG and the PPAR-γ-activated gene ANGPTL4 (Fig. 2A) and triggered synthesis and the nuclear localization of PPAR-γ (Fig. 2B). The gene discussed is ANGPTL4; the disease is malignant colon neoplasm.