HAVCR2 and fibrosarcoma: Treating a DC cell line with lipopolysaccharide and the TIM3 ligand galectin-9 significantly increased TNF-α production.95 However, TIM3 has also been shown to dampen inflammation by interfering with the engagement of DNA-specific TLRs.96 TIM3 blockade improves antitumor DC-T cell crosstalk by enhancing cross-presentation by CD103+ DCs,91 and increasing DC expression of CXCL9, a T cell chemoattractant.97 Interestingly, in a fibrosarcoma model, DCs were required for anti-TIM3-enhanced chemotherapy efficacy.