PDCD1 and neoplasm: PD-1/PD-L1 blockade is able to rescue glycolysis, which is correlated with enhanced antibody-dependent phagocytosis.20 PD-1-deficient myeloid cells exhibit altered development from common myeloid progenitors, with diminished accumulation of granulocyte/macrophage progenitors in the bone marrow and increased expansion of Ly6C+ monocytes and dendritic cells (DCs) within the tumor.15 These data suggest that PD-1 signaling in myeloid progenitors may direct myelopoiesis toward the granulocytic lineage, resulting in greater numbers of immunosuppressive granulocytic-MDSCs.