SOX2 and neoplasm: Xenograft tumor of HCT 116 showed an increased expression of neuronal genes MAP2 and SYN1, neural stemness genes CDH2, MSI1, NCAM1, SOX2/9, VIM and ZEB2 (Fig. 6a), and genes for mesodermal and endodermal tissues (ACP5, AFP, DESMIN, HNF4A and KRT8) (Fig. 6b).