Quantitative RT-PCR (RT-qPCR) revealed that genes representing mesodermal (T, Kdr), endodermal (Foxa2, Gata4/6, Sox17) and ectodermal (Fgf5, Sox11 for primitive ectoderm) differentiation were generally activated in tumor (Fig. 1e). The gene discussed is GATA4; the disease is neoplasm.