BRCA1 and cancer: Around the same time, by screening 1068 breast cancer and 231ovarian cancer cases and performing complete BRCA1/2 sequencing for a selected cohort of 160 cases, another group in Latvia concluded that the prevalence of non-founder BRCA1/2 PV did not likely exceed 0.5% (CI 95% 0.1–0.9%) among unselected breast cancer cases and 1% (CI 95% 0–2.3%) among unselected ovarian cancer cases [5].