The early studies between years 1999–2005 by several groups in Latvia showed that two variants, c.5266dupC and c.4035delA constitute more than 80% of all PV identified by analysis of the entire BRCA1 gene and they contribute to 3,7–5.7% and 9.9–17.3% of all consecutive breast and ovarian cancers respectively [2–6]. Here, BRCA1 is linked to ovarian cancer.