GBA1 and Parkinson disease: While the presence of the N370S mutation in the GBA gene is responsible for improper folding, increased retention of the protein in the ER, and increased lysosomal cholesterol accumulation, and thus reduced lysosomal GCase activity in gPD-GBA N370S group of cells [9], the reduced trafficking of GBA to lysosomes due to decreased LIMP2 levels could be responsible for the significantly reduced GCase enzymatic activity in the idiopathic PD cohort.