Although GM-CSF signaling in microglia is not critical for EAE development [66], further analysis is warranted to define if GM-CSF produced by microglia contribute to EAE by regulating Tregs or other immune cells and if microglia from Prdm1fl/flFoxP3YFP-Cre mice display a “neurotoxic” profile [67] that regulates demyelination or remyelination process during CNS autoimmunity. Here, CSF2 is linked to Autoimmunity.