Considering the recent finding that IgE autoantibodies contribute to autoimmunity without allergic manifestation [54–56], the ongoing therapy for other autoimmune disorders using IgE blocker (omalizumab) [54, 57], and the positive correlation of serum IgE titers with EAE scores reported in this study as well as increased IgE in some MS patients from other reports [58, 59], understanding of its direct contribution to EAE and MS is of key importance. This evidence concerns the gene IGHE and autoimmune disease.