Considering the relation between the stress oxidative, development of diabetes complications, the role of SPTC components, and endurance exercise in improving antioxidant and anti-inflammatory abilities, we hypothesized that utilizing the variance capacity of Nrf2-keap1 complex through exercise and medication with SPTC, might be more efficient to stimulate Nrf2 detachment of keap1 and regulate diabetic related oxidative stress. Here, NFE2L2 is linked to diabetes mellitus.