Considering the relation between the stress oxidative, development of diabetes complications, the role of SPTC components, and endurance exercise in improving antioxidant and anti-inflammatory abilities, we hypothesized that utilizing the variance capacity of Nrf2-keap1 complex through exercise and medication with SPTC, might be more efficient to stimulate Nrf2 detachment of keap1 and regulate diabetic related oxidative stress. The gene discussed is KEAP1; the disease is diabetes mellitus.