SFRP1 and Myocardial fibrosis: In the present study, Sfrp1 overexpression in aged mice partially inhibited myocardial remodeling, improved cardiac function, reduced inflammatory cell infiltration, improved myocardial necrosis and fibroplasia symptoms, inhibited cardiac fibroplasia, improved the abnormal deposition of cardiac ECM (Col-1), decreased the degree of myocardial fibrosis, and inhibited the apoptosis rate of cardiomyocytes.