SFRP1 and Myocardial fibrosis: The results showed that after transduction of AAV-Sfrp1, Sfrp1 was successfully overexpressed in the myocardium of aged mice and could remarkably reduce Wnt/β-catenin pathway activity in aged mice after AMI, effectively reducing the degree of myocardial fibrosis, inhibiting cardiomyocyte apoptosis, and improving cardiac function.