However, when Sfrp1 was overexpressed, the cardiaomyocyte apoptosis rate was obviously reduced in the M3 + Sfrp1 group and M7 + Sfrp1 group compared to the corresponding MI group (Fig. 4 a-b and Table 2), indicating that Sfrp1 overexpression can effectively inhibit cardiomyocyte apoptosis in aged mice with AMI injury. The gene discussed is SFRP1; the disease is myocardial infarction.