HAND2-AS1 is a newly defined long non-coding RNA (lncRNA) and has been proved play an important role in different types of tumors, such as prostate cancer [19], ovarian carcinoma [20], cervical cancer [21], intraductal papillary mucinous neoplasm [22], colorectal cancer [23], liver cancer [24], and liver cancer stem cell [25]. This evidence concerns the gene HAND2 and liver cancer.