SQSTM1 and acute myeloid leukemia: In this study, we found that FA exposure significantly stimulated hepatic autophagy in AML-12 cells, as evidenced by the observation of increased Beclin1 expression and LC3 II conversion, both of which are well-established markers of autophagy induction, and reduced expression of p62, a protein specifically degraded by autophagy, induced by FA in a dose-dependent and time-dependent manner (Fig. 3a, b).