The MiR-182-5p → GSK3B regulatory pair was found in the miRNA-TF-gene regulatory network; therefore, miR-182-5p may also be implicated in the development of OA by mediating GSK3B. MDM2 expression in the fibroblast-like synoviocytes of RA patients was upregulated compared to that of OA patients, which may help to reduce apoptosis of lining tissues in RA [40]. This evidence concerns the gene TF and rheumatoid arthritis.