In this study, a series of bioinformatics analysis identified 6 common DEGs (IFI27, IFI44, IFI44L, EPSTI1, OAS1) between SLE and normal samples based on gene expression profiles obtained from GSE50772, GSE81622(LN), GSE81622(SLE), GSE144390, GSE4588(B Cell), GSE4588(CD4 T Cell) and GSE144390 datasets. This evidence concerns the gene EPSTI1 and systemic lupus erythematosus.