CDKN3 and neoplasm: According to the Gene Expression Profiling Interactive Analysis (GEPIA) database (http://gepia.cancer-pku.cn/index.html) [19], CDKN3 is expressed at higher levels in tumor samples than in normal tissue, and its levels were positively correlated with pathologic stage, and could predict unfavorable OS and disease-free survival outcomes in the ccRCC TCGA dataset (Additional file 6: Fig. S3B-E).