Additional file 1: Fig. S4 shows the cost-effectiveness acceptability curves; based on three times Taiwan’s GDP, the probabilities of using a GLP-1RA versus insulin therapy being cost-effective for preventing one case of all-cause mortality and hospitalized hypoglycemia were 60% (100%) and 80% (100%), respectively, from the payer perspective (healthcare sector perspective). The gene discussed is INS; the disease is Hypoglycemia.