Univariable Cox proportional hazards analysis showed that high Fuhrman grade, high TV and advanced pT classification were all associated with poor OS, CSS, FFLR and FFM of localized ccRCC after surgery, but tumor necrosis and Ki-67 did not predict the oncological outcome independently (P < 0.05 for all; Tables 2, 3, 4 and 5). The gene discussed is MKI67; the disease is neoplasm.