Taking into account that people with diabetes perform around 16 scans per day [3], and therapy decisions (exogenous insulin administration and carbohydrates intake) of particular people with type 1 diabetes (T1D) are based on the sensor glucose levels accompanied by trend arrows that indicate the rate of change in glucose levels, there is a need to investigate isCGM under different glycemic challenges [4]. This evidence concerns the gene INS and type 1 diabetes mellitus.