For instance, pentamidine inhibits the interaction between p53 and S100B, thus reactivating the transcriptional activity of p53 apoptosis in cancer cells; also, pentamidine decreases gliosis and neuroinflammation in a mouse model of Aβ-induced Alzheimer’s Disease (AD) suggesting an inhibitory activity over the interaction between S100B and RAGE (receptor for advanced glycation end-products) [9], similarly to other S100 proteins [10]. This evidence concerns the gene TP53 and early-onset autosomal dominant Alzheimer disease.