On the other hand, studies on cancer cells such as HeLa cells (cervical cancer) [156], 9L glioma cells (brain tumor) [217], breast cancer cells [175,177], ovarian cancer cells, colon cancer cells and lung cancer cells [175] show that chronic hypoxia reduces the expression of CXCL10, as in studies on noncancer cells such as primary hepatocytes [178] and rabbit alveolar macrophages [201]. The gene discussed is CXCL10; the disease is breast cancer.