Two independent studies have reported the compensatory upregulation of ICs, including lymphocyte activation gene-3 (LAG-3), T-cell immunoglobulin and mucin domain-3 (TIM-3) and CTLA-4, on CD8+ T cells after PD-1 blockade in immunocompetent murine models of ovarian cancer and lung adenocarcinoma [44,45]. This evidence concerns the gene HAVCR2 and lung adenocarcinoma.