Though the results obtained for AChE inhibition for compounds 1–3 are in the micromolar range and relatively similar to TA, these compounds present improved inhibition of Aβ aggregation, metal chelation capacity, potential oral absorbance and are non-cytotoxic towards SH-SY5Y human neuroblastoma cell line which makes them good building blocks for the development of future anti-neurodegenerative drugs. Here, ACHE is linked to neuroblastoma.